Pharmacokinetic data suggests a 20-fold increase in relative absorption compared to standard curcumin. Curcumin is included in this formula as clinically researched and patented Meriva ® curcumin-phosphatidylcholine complex, which offers enhanced efficiency of absorption and resistance to degradation in the digestive tract. Resveratrol supports the activity of Nrf2, a transcription factor that supports cellular function by promoting protection against oxidative stress.
This formula provides cellular protection against oxidative stress by promoting numerous enzyme and gene transcription pathways. Research suggests vitamin D supports healthy cellular response, in part by modulating this pathway. NLRP (NOD-like receptor proteins) act as intracellular sensors to oxidative and environmental stressors. Yanuck, an internationally recognized immunology thought leader and educatorįoundational support for healthy immune response, bone health and antioxidant statusīalanced Immune is designed to support immune balance and tissue health, in part by targeting the NLRP and NF-κB pathways to modulate cytokine production. The B 12 in this formula is provided as methylcobalamin, the most bioavailable form of this vitamin.įormulated with Dr. Through bypassing several enzymatic activation steps, it is directly usable by the body and provides all of the benefits of folic acid regardless of functional or genetic variations. L-5-MTHF is the predominant, naturally occurring form of folate in food. Metafolin ® is chemically identical to the active folate metabolite, 5-methyltetrahydrofolate (L-5-MTHF). Folate is provided in this formula as Metafolin ®, the universally metabolized form of folate. Folate promotes healthy cellular differentiation during the formation of the brain and spinal cord, helping to reduce the risk of neural tube defects when taken daily prior to becoming pregnant and during early pregnancy. At the molecular level, the main function of folate is to donate methyl groups in key biochemical reactions.Īdequate folate status is particularly critical for proper neural and cellular development of the fetal central nervous system.
They are also critical for maintaining red blood cell homeostasis, as they help form red blood cells. They are vital to the metabolism of nutrients and are both required by the enzyme that produces methionine.
Folate and vitamin B 12 are interrelated in function. B vitamins act as cofactors and methyl donors in a variety of key biochemical reactions occurring in blood cells, neurons, the vasculature, and many other tissues.ī 12 Folate is a combination of two water-soluble B vitamins, folate and vitamin B 12. Healthy methylation is vital for cellular health, DNA synthesis, hormone, and neurotransmitter production and energy metabolism. Methylation is a key regulator of gene expression and cellular function. B vitamins are essential to basal mitochondrial function as metabolic coenzymes, playing a key role in energy production and nutrient metabolism.ī vitamins also play a critical role in promoting DNA synthesis and healthy methylation. Optimal levels of B vitamins have been associated with cellular, cardiovascular, neurological and psychological health. Some of the key supportive roles include nutrient and energy metabolism, as well as the production of DNA, hemoglobin, neurotransmitters, and hormones. Pure Encapsulations B-Complex Plus, As a complex, B vitamins play important roles in nearly all of the physiological systems in the body. In another randomized, double-blind study, three-month acetyl-l-carnitine supplementation provided statistically significant support for mental function, including memory and attention, compared to placebo.
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A multicenter trial of 481 volunteers indicated memory and behavioral support with acetyl-l-carnitine supplementation. The acetyl group from acetyl-l-carnitine is also responsible for the production of acetylcholine, an important neurotransmitter for optimal mental functioning. In addition, it supports healthy mitochondrial function and cell membrane stability. It is the acetylated form of l-carnitine, and the two compounds share similar energy- and metabolism-promoting properties.įound naturally in the body, acetyl-l-carnitine supports the availability of acetyl-CoA, an important energy-generating metabolite.
Supports cognitive health and brain function by promoting cellular and neuronal healthĪcetyl-l-Carnitine is a building block for proteins that helps support cognitive health and brain function by producing energy, as well as stabilizing cell membranes.
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